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? Ebook Radiotracers in Drug DevelopmentFrom CRC Press

Ebook Radiotracers in Drug DevelopmentFrom CRC Press

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Radiotracers in Drug DevelopmentFrom CRC Press

Radiotracers in Drug DevelopmentFrom CRC Press



Radiotracers in Drug DevelopmentFrom CRC Press

Ebook Radiotracers in Drug DevelopmentFrom CRC Press

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Radiotracers in Drug DevelopmentFrom CRC Press

Although there are numerous books on drug metabolism, Radiotracers in Drug Development is unique in explaining how radiotracers are used to elucidate a drug’s absorption, distribution, metabolism, and excretion (ADME). Covering traditional and recent technologies and applications, the book takes a strong industrial approach, discussing the basics of scintillation counting and untangling the various data processing methods often specific to individual manufacturers.

The chapters include descriptions of the latest micro-plate counters and the growing applications of accelerator mass spectrometry, positron emission tomography, gamma-scintigraphy, and radioluminography. In addition to describing how the analytical technologies work, the contributors explain how the data are interpreted and used in the drug registration process.

A unique reference and training aid essential for every drug metabolism department or drug metabolism research team, the book provides insight into the use and practice of ADME in a way that is both instructive and practical. Moving easily across the boundaries of biology, chemistry, and physics, this is the only comprehensive, interdisciplinary resource covering the how-tos of employing radiotracers in drug development. It provides detailed information on how the science is relevant to the registration process.

  • Sales Rank: #4593074 in Books
  • Published on: 2006-04-03
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.56" h x .83" w x 6.27" l, 1.34 pounds
  • Binding: Hardcover
  • 320 pages

Review
…a well-structured and easily readable book with clear illustrations (a few in colour) and a comprehensive, 10 page, index. It will serve as a good introductory text to students and others who wish to gain a basic understanding of the application of radioisotopes in drug metabolism and disposition studies; I will certainly recommend it to students and new starters in our own department.
- Andy Gray, AstraZeneca, UK, bts (The British Toxicology Society, Newsletter, Winter 2006, Issue 29

It is a well planned, laid out, and written tome. The listing of 278 pertinent references and further reading material, together with tables, formulae both chemical and mathematical, schematics, diagrams, graphs, and photographs (7 in colour) enhance the text. …The authors have succeeded in putting this fine work together. It is filled with a wealth of interesting, relevant and practical information and I would consider it mandatory reading for anyone already within or about to enter the field of xenobiochemistry.
-Steve Mitchell, Imperial College London, South Kensington, UK, the ISSX (International Society for the Study of Xenobiotics) Newsletter, Winter 2006 / Spring 2007 edition

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