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Particle ToxicologyFrom CRC Press
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Exposure to particles in industry and mining and from accidental anthropogenic sources constitutes an ongoing threat. Most recently nanoparticles arising from advances in technology are exposing a wider population to pathogenic stimuli. The effects of inhaled particles are no longer confined to the lung as nanoparticles have the potential to translocate to the bloodstream, the brain, and other target sites. The new questions posed by nanoparticles underscore the importance of interdisciplinary research and exchange and highlight the need for new collaborations among disciplines in medicine, toxicology, chemistry, and material sciences.
Particle Toxicology brings together the state of the science in particle physico-chemistry, cell biology, and toxicology in a single volume. While organized around the classical toxicology paradigm of exposure - dose - response, the book is unique in its emphasis on mechanistic toxicology. Preparing the reader with a brief historical overview and a conceptual framework for particle research, the book provides reviews on the mechanisms and properties of pathogenic particles and their effects on target cells at various sites in the body. The text describes how adverse effects are a consequence of deposition, translocation, and the complex issue of “dose” dominates. Contributions from leading researchers address particle-associated pro-inflammatory effects and inflammatory signaling, cellular and extracellular oxidative and nitrosative stress, particulate interactions in the pulmonary, cardiovascular, and central nervous systems, as well as genotoxic effects. Exemplar particles include quartz, asbestos, particulate material and nanoparticles. The book also covers mathematical modeling and human studies as avenues for future research.
Responding to the evolving trend of consumer applications for particulate matter, Particle Toxicology provides the comprehensive resource for current knowledge from which to develop new concepts to understanding particle actions, measurement, testing, and pathogenic exposure to fine and ultrafine particles.
- Sales Rank: #6485945 in Books
- Published on: 2006-12-21
- Original language: English
- Number of items: 1
- Dimensions: 10.32" h x 1.15" w x 7.12" l, 2.15 pounds
- Binding: Hardcover
- 456 pages
Review
This well-written book…fully meets the challenge of insightfully summarizing and critically reviewing the state of the science for particle toxicology. …Special attention has been given to reviewing nanoparticle research. …The first few chapters are a must-read in terms of understanding the significance of the problem…. The authors have presented a clear and authoritative account of what is known about particle toxicology as well as indications of what is unknown. References are reviewed in depth, relevant areas are covered, and the information is presented in a manner that can be grasped by research academics, industrial scientists, and students, as well as those individuals responsible for establishing regulatory policies…. The chapters are rich with graphs, figures, microphotographs, and tables…. The strength of this book lies in its in-depth coverage of particle toxicology in terms of models, methods, risk assessment, and health effects. …The authors are to be congratulated for taking on this difficult but important task and carrying it out so well….
-Donald E. Gardner, Editor-in-Chief, Inhalation Toxicology, 19:787-788, 2007
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